Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists

Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists

A novel series of aminomethyl substituted thieno[2,3-d]pyrimidines have been identified as adenosine A2A receptor antagonists. Analogues show excellent in vitro activities and have excellent activity in vivo in mouse models of Parkinson's disease.

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Veröffentlicht in:MedChemComm 2011, Vol.2 (10), p.950-965
Hauptverfasser: Shook, Brian C., Charavarty, Devraj, Barbay, J. Kent, Wang, Aihua, Leonard, Kristi, Alford, Vernon, Powell, Mark, Beauchamp, Derek A., Rassnick, Stefanie, Scannevin, Robert, Carroll, Karen, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Lampron, Lisa, Westover, Lori, Rhodes, Kenneth, Jackson, Paul F.
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Sprache:eng
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Zusammenfassung:A novel series of aminomethyl substituted thieno[2,3-d]pyrimidines have been identified as adenosine A2A receptor antagonists. Analogues show excellent in vitro activities and have excellent activity in vivo in mouse models of Parkinson's disease.
ISSN:2040-2503
2040-2511
DOI:10.1039/c1md00082a