Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

A panel of stable [Au(R-C--N--C)(N-heterocyclic carbene)](+) complexes displays prominent in vitro anticancer properties; [Au(C--N--C)(IMe)]CF(3)SO(3) (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2010-06, Vol.46 (22), p.3893-3895
Hauptverfasser:	Yan, Jessie Jing, Chow, Andy Lok-Fung, Leung, Chung-Hang, Sun, Raymond Wai-Yin, Ma, Dik-Lung, Che, Chi-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Carcinoma, Hepatocellular - drug therapy Computer Simulation Coordination Complexes - chemistry Coordination Complexes - therapeutic use Coordination Complexes - toxicity DNA Topoisomerases, Type I - metabolism Gold - chemistry Hep G2 Cells Heterocyclic Compounds - chemistry Humans Ligands Liver Neoplasms - drug therapy Methane - analogs & derivatives Methane - chemistry Mice Mice, Nude Topoisomerase I Inhibitors
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Beschreibung
Zusammenfassung:	A panel of stable [Au(R-C--N--C)(N-heterocyclic carbene)](+) complexes displays prominent in vitro anticancer properties; [Au(C--N--C)(IMe)]CF(3)SO(3) (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c001216e