Diversification of Animal Venom Peptides-Were Jellyfish Amongst the First Combinatorial Chemists?

Diversification of Animal Venom Peptides-Were Jellyfish Amongst the First Combinatorial Chemists?

An ocean of data: Huge numbers of protein toxins are found in animal venoms. This diversity is widely believed to have arisen by gene duplication events. However, recent data now challenges this tradition view. Here we highlight how jellyfish could hold the key to unravelling toxin diversification,...

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2013-08, Vol.14 (12), p.1407-1409
Hauptverfasser: Starcevic, Antonio, Long, Paul F.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chemistry Techniques, Synthetic
Cnidaria
Cnidarian Venoms - chemistry
Cnidarian Venoms - genetics
drug design
Evolution, Molecular
Gene Duplication
molecular evolution
Peptides - chemistry
Peptides - genetics
Scyphozoa - chemistry
Scyphozoa - classification
toxins
venoms
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Beschreibung
Zusammenfassung:An ocean of data: Huge numbers of protein toxins are found in animal venoms. This diversity is widely believed to have arisen by gene duplication events. However, recent data now challenges this tradition view. Here we highlight how jellyfish could hold the key to unravelling toxin diversification, with a view towards future combinatorial biosynthesis of toxin libraries.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201300305