A case of NUT midline carcinoma with no HPV infection, slight EWSR1 rearrangement and strong expression of EGFR

NUT midline carcinoma (NMC) is a rare neoplasm with a poor prognosis and involving mostly young patients. Here we describe a classic NMC with a BRD4-NUT fusion gene in a middle-aged woman. We also analyzed some biological features that could potentially influence its clinical behavior such as HPV in...

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Veröffentlicht in:	Tumori 2013-07, Vol.99 (4), p.e152-e155
Hauptverfasser:	Maffini, Fausto, French, Christopher Alexander, Cameron, Michael James, Stufano, Viviana, Barberis, Massimo, Pisa, Eleonora, Manzotti, Michela, Cattaneo, Augusto, De Fiori, Elvio, Viale, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Calmodulin-Binding Proteins - genetics Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Female Gene Expression Regulation, Neoplastic Gene Rearrangement Genes, erbB-1 Humans Immunohistochemistry In Situ Hybridization, Fluorescence Laryngeal Neoplasms - genetics Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Laryngeal Neoplasms - surgery Lymphatic Metastasis Middle Aged Nuclear Proteins - genetics Oncogene Proteins, Fusion - genetics Receptor, Epidermal Growth Factor - genetics RNA-Binding Protein EWS RNA-Binding Proteins - genetics
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Zusammenfassung:	NUT midline carcinoma (NMC) is a rare neoplasm with a poor prognosis and involving mostly young patients. Here we describe a classic NMC with a BRD4-NUT fusion gene in a middle-aged woman. We also analyzed some biological features that could potentially influence its clinical behavior such as HPV infection, EWSR1 rearrangement, and the status of the EGFR gene.
ISSN:	2038-2529
DOI:	10.1700/1361.15114