Solvent- and Catalyst-Free Huisgen Cycloaddition to Rufinamide in Flow with a Greener, Less Expensive Dipolarophile

Give it a flow: A continuous‐flow process for the synthesis of a 1,2,3‐triazole precursor of Rufinamide has been developed. The protocol involves a solvent‐ and catalyst‐free operation and utilizes reaction temperatures above the melting point of the target product to prevent microreactor clogging,...

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Veröffentlicht in:	ChemSusChem 2013-12, Vol.6 (12), p.2220-2225
Hauptverfasser:	Borukhova, Svetlana, Noël, Timothy, Metten, Bert, de Vos, Eric, Hessel, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis cycloaddition Cycloaddition Reaction green chemistry microflow chemistry novel process windows solvent free Solvents Triazoles - chemistry
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creator	Borukhova, Svetlana Noël, Timothy Metten, Bert de Vos, Eric Hessel, Volker
description	Give it a flow: A continuous‐flow process for the synthesis of a 1,2,3‐triazole precursor of Rufinamide has been developed. The protocol involves a solvent‐ and catalyst‐free operation and utilizes reaction temperatures above the melting point of the target product to prevent microreactor clogging, resulting in a decrease of the operating time from hours to minutes.
doi_str_mv	10.1002/cssc.201300684
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subjects	Catalysis cycloaddition Cycloaddition Reaction green chemistry microflow chemistry novel process windows solvent free Solvents Triazoles - chemistry
title	Solvent- and Catalyst-Free Huisgen Cycloaddition to Rufinamide in Flow with a Greener, Less Expensive Dipolarophile
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