Solvent- and Catalyst-Free Huisgen Cycloaddition to Rufinamide in Flow with a Greener, Less Expensive Dipolarophile

Give it a flow: A continuous‐flow process for the synthesis of a 1,2,3‐triazole precursor of Rufinamide has been developed. The protocol involves a solvent‐ and catalyst‐free operation and utilizes reaction temperatures above the melting point of the target product to prevent microreactor clogging, resulting in a decrease of the operating time from hours to minutes.