Functionalized Bis-enol Acetates as Specific Molecular Probes for Esterases

Modeled after nature: The wound‐sealing reaction of green algae guided the development of hydrolase‐reactive probes for the specific labeling of esterases. These diagnostic tools react selectively with esterases (even in the presence of other hydrolytic enzymes) by forming covalent adducts.

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Bibliographische Detailangaben
Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2013-12, Vol.14 (18), p.2435-2438
Hauptverfasser:	Richter, Phillipp, Weißflog, Jerrit, Wielsch, Natalie, Svatoš, Aleš, Pohnert, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Animals Caulerpa - chemistry Caulerpa taxifolia enzymes Esterases - analysis fluorescent probes Humans hydrolases lipases Models, Molecular Molecular Probes - chemistry Sesquiterpenes - chemistry
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Beschreibung
Zusammenfassung:	Modeled after nature: The wound‐sealing reaction of green algae guided the development of hydrolase‐reactive probes for the specific labeling of esterases. These diagnostic tools react selectively with esterases (even in the presence of other hydrolytic enzymes) by forming covalent adducts.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201300556