A positive effect of immune suppression on corrected count increment after platelet transfusion at 1 but not at 24h

The effects of patient characteristics on corrected count increment (CCI) in hemato-oncology patients were studied. CCI values were 13.6±6.5 (1h, n=79) and 6.3±5.3 (24h, n=69). With concomitant immune suppression CCI was higher at 1h (20.0±7.9 versus 13.2±6.3, p=0.023), but not at 24h (5.9±6.7 versus 6.3±5.2; p=0.88). The observed effect is short lived, potentially benefiting bleeding patients, but may not increase intervals between transfusions. Further, CCI1h was lower if fever was present (9.7±3.6 versus 14.3±6.7; p=0.002), and corresponding CCI24h values were 3.7±6.3 versus 6.7±5.0 (p=0.09). At 24h an effect for previous transfusions was observed, 6.7±5.1 (with) versus 1.6±5.4 (without p=0.02).