Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring

A new series of thiazolidinedione derivatives were synthesized and evaluated for in vitro α-glucosidase inhibition and anticancer activities. Compounds 3d, 3e and 3j showed potential α-glucosidase inhibition with IC50 values ranging between 0.1 and 0.3 μg/ml whereas compounds 3i, 3j and 3k have show...

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Veröffentlicht in:	European journal of medicinal chemistry 2013-12, Vol.70, p.308-314
Hauptverfasser:	Chinthala, Yakaiah, Kumar Domatti, Anand, Sarfaraz, Alam, Singh, Shailendra Pratap, Kumar Arigari, Niranjan, Gupta, Namita, Satya, Srinivas K.V.N., Kotesh Kumar, Jonnala, Khan, Feroz, Tiwari, Ashok K., Paramjit, Grover
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3-Triazoles alpha-Glucosidases - metabolism Anticancer activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glycoside Hydrolase Inhibitors Hep G2 Cells Humans MCF-7 Cells Models, Molecular Molecular modeling study Molecular Structure Structure-Activity Relationship Thiazolidinediones Thiazolidinediones - chemical synthesis Thiazolidinediones - chemistry Thiazolidinediones - pharmacology Triazoles - chemistry α-Glucosidase inhibition
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