Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring

A new series of thiazolidinedione derivatives were synthesized and evaluated for in vitro α-glucosidase inhibition and anticancer activities. Compounds 3d, 3e and 3j showed potential α-glucosidase inhibition with IC50 values ranging between 0.1 and 0.3 μg/ml whereas compounds 3i, 3j and 3k have showed better anticancer activity towards human cancer cell lines IMR-32 (neuroblastoma), Hep-G2 (hepatoma) and MCF-7 (breast). Molecular docking studies revealed compounds 3d, 3e and 3j are potent inhibitors of α-glucosidase and also showed compliance with standard parameters of drug likeness. [Display omitted] •Several thiazolidiendiones tagged with 1,2,3-triazoles were synthesized.•Compounds 3d, 3e and 3j showed significant α-glucosidase inhibition activity.•The cytotoxic activity of compounds was assessed using MTT reduction assay.•Docking results of 3d, 3e and 3j with α-glucosidase were comparable with Acarbose.