Prevention of diabetes in biobreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells

Prevention of diabetes in biobreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells

Diabetes-prone BioBreeding/Worcester (BB/Wor) rats received thrice weekly injection of mAb against antigens expressed on the surface of all T cells (OX19), cytotoxic/suppressor, and NK cells (OX8), helper/inducer cells (W3/25, OX35, OX38),and Ia super(+) cells (OX6. 3JP. OX17). Treatment with OX8 or...

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Veröffentlicht in:The Journal of experimental medicine 1986-01, Vol.164 (1), p.1145-1159
Hauptverfasser: Like, A A, Biron, CA, Weringer, E J, Byman, K, Sroczynski, E, Guberski, D L
Format: Artikel
Sprache:eng
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Zusammenfassung:Diabetes-prone BioBreeding/Worcester (BB/Wor) rats received thrice weekly injection of mAb against antigens expressed on the surface of all T cells (OX19), cytotoxic/suppressor, and NK cells (OX8), helper/inducer cells (W3/25, OX35, OX38),and Ia super(+) cells (OX6. 3JP. OX17). Treatment with OX8 or OX19 achieved stable reductions of splenic and peripheral blood NK cells and helper/inducer T lymphocytes, respectively, and protected against diabetes. The findings suggest that pancreatic beta cell destruction in the spontaneously diabetic BB/Wor rat is mediated by the combined action of NK and helper/inducer cells.
ISSN:0022-1007