The human V sub( Kappa ) locus: Characterization of extended immunoglobulin gene regions by cosmid cloning

The human V sub( Kappa ) locus: Characterization of extended immunoglobulin gene regions by cosmid cloning

The authors screened cosmid libraries with V sub( Kappa ) gene probes and obtained numerous V) sub( Kappa ) gene-containing cosmid clones. The regions that are called Wa, Wb, Oa, Ob and Ob' comprise about 370 kb (10 super(3) bases) of DNA and contain 24 V) sub( Kappa ) genes and pseudogenes. Th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of molecular biology 1987-01, Vol.193 (2), p.241-253
Hauptverfasser: Pohlenz, H-D, Straubinger, B, Thiebe, R, Pech, M, Zimmer, F-J, Zachau, H G
Format: Artikel
Sprache:eng
Schlagworte:
cloning vectors
cosmids
gene mapping
genes
immunoglobulins
man
pseudogenes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The authors screened cosmid libraries with V sub( Kappa ) gene probes and obtained numerous V) sub( Kappa ) gene-containing cosmid clones. The regions that are called Wa, Wb, Oa, Ob and Ob' comprise about 370 kb (10 super(3) bases) of DNA and contain 24 V) sub( Kappa ) genes and pseudogenes. The V) sub( Kappa ) genes belong to the three dominant subgroups (V sub( Kappa )I, V sub( Kappa )II, V sub( Kappa )III) and are arranged to form mixed clusters with members of the different subgroups being intermingled with each other.
ISSN:0022-2836