Definitions and Pathophysiology of Sepsis

Mortality rates for sepsis and septic shock have not improved in the past decade. The Surviving Sepsis Campaign (SSC) guidelines released in 2012 emphasize early recognition and treatment of sepsis, in an effort to reduce the burden of sepsis worldwide. This series of review articles will discuss th...

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Veröffentlicht in:	Current problems in pediatric and adolescent health care 2013-11, Vol.43 (10), p.260-263
Hauptverfasser:	Sagy, Mayer, MD, Al-Qaqaa, Yasir, MD, Kim, Paul, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents - therapeutic use Child Comorbidity Fluid Therapy - methods Humans Inflammation - immunology Inflammation - physiopathology Inflammation Mediators - immunology Multiple Organ Failure - immunology Multiple Organ Failure - physiopathology Pediatrics Practice Guidelines as Topic Resuscitation - methods Sepsis - drug therapy Sepsis - immunology Sepsis - physiopathology Severe Acute Respiratory Syndrome - immunology Severe Acute Respiratory Syndrome - physiopathology Severity of Illness Index
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Beschreibung
Zusammenfassung:	Mortality rates for sepsis and septic shock have not improved in the past decade. The Surviving Sepsis Campaign (SSC) guidelines released in 2012 emphasize early recognition and treatment of sepsis, in an effort to reduce the burden of sepsis worldwide. This series of review articles will discuss the pathophysiology of sepsis; comorbidities, such as multiorgan dysfunction syndrome (MODS), acute respiratory distress syndrome (ARDS), and endocrine issues; and finally, management of sepsis and septic shock.
ISSN:	1538-5442 1538-3199
DOI:	10.1016/j.cppeds.2013.10.001