Human leukocyte antigen B distribution in HIV discordant cohort from India

Human leukocyte antigen B distribution in HIV discordant cohort from India

Highlights • HLA-B*35 is significantly associated with susceptibility to HIV infection. • HLA-B*40 (specifically *B40:06);-B*18 is significantly associated with protection. • Identified HLA-B alleles can be used as predictive marker of HIV transmission. • HLA-B*5701 testing for prevention of adverse...

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Veröffentlicht in:Immunology letters 2013-11, Vol.156 (1), p.1-6
Hauptverfasser: Chaudhari, Deepali V, Chavan, Vijay R, Ahir, Swati P, Kerkar, Shilpa C, Mehta, Preeti R, Mania-Pramanik, Jayanti
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Allergy and Immunology
Cohort Studies
Female
Gene Frequency
Histocompatibility Testing - methods
HIV Infections - genetics
HIV Infections - immunology
HIV Infections - virology
HIV serodiscordant
HIV Seronegativity - genetics
HIV Seronegativity - immunology
HIV Seropositivity - genetics
HIV Seropositivity - immunology
HIV Seropositivity - virology
HIV-1 - immunology
HIV-1 - physiology
HLA
HLA-B Antigens - genetics
HLA-B Antigens - immunology
HLA-B18 Antigen - genetics
HLA-B18 Antigen - immunology
HLA-B35 Antigen - genetics
HLA-B35 Antigen - immunology
HLA-B40 Antigen - genetics
HLA-B40 Antigen - immunology
Host-Pathogen Interactions - immunology
Humans
India
Male
Protective alleles
Spouses
Susceptibility
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Beschreibung
Zusammenfassung:Highlights • HLA-B*35 is significantly associated with susceptibility to HIV infection. • HLA-B*40 (specifically *B40:06);-B*18 is significantly associated with protection. • Identified HLA-B alleles can be used as predictive marker of HIV transmission. • HLA-B*5701 testing for prevention of adverse drugs reaction.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2013.09.002