Distinct regulation of Th2 and Th17 responses to allergens by pulmonary antigen presenting cells in vivo

Highlights • Th17 responses and neutrophilia are enhanced in the lung of mice depleted of CD11c+ cell or macrophage. • Th2 responses, eosinophilia and AHR are diminished in the lung of mice depleted of CD11c+ cell or macrophage. • MHC II expression on lung epithelial cells is dispensable for the gen...

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Veröffentlicht in:	Immunology letters 2013-11, Vol.156 (1), p.140-148
Hauptverfasser:	Lim, Hoyong, Kim, Young Uk, Yun, Kyoungah, Drouin, Scott M, Chung, Yeonseok
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergen Allergens - immunology Allergy and Immunology Animals Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Aspergillus - immunology Aspergillus - metabolism CD11c Antigen - genetics CD11c Antigen - immunology CD11c Antigen - metabolism CD11c+ dendritic cell Cytokines - immunology Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Eosinophils - immunology Eosinophils - metabolism Fungal Proteins - immunology Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Lung - immunology Lung - metabolism Lung - pathology Lung inflammation Macrophage Macrophages - immunology Macrophages - metabolism Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Mice, Transgenic Peptide Hydrolases - immunology Pneumonia - genetics Pneumonia - immunology Pneumonia - metabolism Th17 Th17 Cells - immunology Th17 Cells - metabolism Th2 Th2 Cells - immunology Th2 Cells - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Th17 responses and neutrophilia are enhanced in the lung of mice depleted of CD11c+ cell or macrophage. • Th2 responses, eosinophilia and AHR are diminished in the lung of mice depleted of CD11c+ cell or macrophage. • MHC II expression on lung epithelial cells is dispensable for the generation of pulmonary Th2 and Th17 cells.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2013.10.003