Supraglottic laryngeal tumor microenvironmental factors facilitate STAT3 dependent pro-tumorigenic switch in tumor associated macrophages to render utmost immune evasion

Highlights • Lysates from laryngeal tumors polarizes non-polarized macrophages to their pro-tumor M2 form. • Supraglottic laryngeal tumor cell lysate (SLTCL) showed maximum M2 polarizing ability. • SLTCL generated M2 macrophages demonstrated maximum IL-10/IL-12 ratio with lesser nitric oxide release...

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Veröffentlicht in:	Immunology letters 2013-11, Vol.156 (1), p.7-17
Hauptverfasser:	Goswami, Kuntal Kanti, Barik, Subhasis, Banerjee, Saptak, Bhowmick, Anup Kumar, Biswas, Jaydip, Bose, Anamika, Baral, Rathindranath
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigen Presentation - drug effects Antigen Presentation - immunology Cell Line, Tumor Cells, Cultured Coculture Techniques Cytotoxicity, Immunologic Epiglottis - metabolism Epiglottis - pathology Glottis - metabolism Glottis - pathology Humans IL-10 Immune Evasion - drug effects Immune Evasion - immunology Immunohistochemistry Immunologic Factors - metabolism Immunologic Factors - pharmacology Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-10 - metabolism Interleukin-12 - genetics Interleukin-12 - immunology Interleukin-12 - metabolism Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Lymphocyte Activation - immunology M2 macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Male Nitric Oxide - immunology Nitric Oxide - metabolism Prognosis Reverse Transcriptase Polymerase Chain Reaction RNA Interference STAT3 STAT3 Transcription Factor - genetics STAT3 Transcription Factor - immunology STAT3 Transcription Factor - metabolism Supraglottic laryngeal tumor T-Lymphocytes - immunology Tissue Extracts - metabolism Tissue Extracts - pharmacology Tumor Microenvironment
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Zusammenfassung:	Highlights • Lysates from laryngeal tumors polarizes non-polarized macrophages to their pro-tumor M2 form. • Supraglottic laryngeal tumor cell lysate (SLTCL) showed maximum M2 polarizing ability. • SLTCL generated M2 macrophages demonstrated maximum IL-10/IL-12 ratio with lesser nitric oxide release. • SLTCL generated M2 macrophages suppressed anti-tumor T cell functions. • M2 character of laryngeal tumor microenvironment might be a causative factor for poor prognosis of laryngeal cancer patients.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2013.09.003