Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient
Abstract We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depe...
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| Veröffentlicht in: | Journal of clinical virology 2013-12, Vol.58 (4), p.733-736 |
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| container_title | Journal of clinical virology |
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| creator | Schnepf, Nathalie Dhédin, Nathalie Mercier-Delarue, Séverine Andreoli, Annalisa Mamez, Anne-Claire Ferry, Christelle Deback, Claire Ribaud, Patricia Robin, Marie Socié, Gérard Simon, François Mazeron, Marie-Christine |
| description | Abstract We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depend on both the selection pressure exerted by the antiviral treatments and the immune response. |
| doi_str_mv | 10.1016/j.jcv.2013.10.007 |
| format | Article |
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Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depend on both the selection pressure exerted by the antiviral treatments and the immune response.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2013.10.007</identifier><identifier>PMID: 24183928</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Allergy and Immunology ; Antiviral Agents - therapeutic use ; Cytomegalovirus ; Cytomegalovirus - genetics ; Cytomegalovirus Infections - drug therapy ; Cytomegalovirus Infections - virology ; Drug Resistance, Viral - genetics ; Female ; Genes, Viral ; Hematopoietic Stem Cell Transplantation ; Humans ; Infectious Disease ; Kinetics ; Mutation ; Resistance ; Stem cell transplantation ; Young Adult</subject><ispartof>Journal of clinical virology, 2013-12, Vol.58 (4), p.733-736</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. 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Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depend on both the selection pressure exerted by the antiviral treatments and the immune response.</description><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - genetics</subject><subject>Cytomegalovirus Infections - drug therapy</subject><subject>Cytomegalovirus Infections - virology</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Female</subject><subject>Genes, Viral</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Kinetics</subject><subject>Mutation</subject><subject>Resistance</subject><subject>Stem cell transplantation</subject><subject>Young Adult</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2O1DAQhSMEYoaBA7BBXrJJ45_EcYSEhAaYQWqJBczaciqVxiGxg-201Bfg3DjqhgULVi4_vVeq-qooXjK6Y5TJN-NuhOOOUybyf0dp86i4ZqoRZd3K5nGuhZKlrAW_Kp7FOFLKalE1T4srXjElWq6ui18fTs7MFiLxA4FT8jMezOSPNqyRLH5ZJ5Osd5F8N6Hza7DuQOY1XUTryAEdRvKwrytiXJ-LttlkkwM4m-QXbzFZIDHhTACniaRgXFwm4xIJCHax6NLz4slgpogvLu9N8fDp47fb-3L_5e7z7ft9CYKLVBo-GGr6rho4KsS2w5pxhVRBRaXqBQclu56BGDgHLrg0AnoBLQOWdYnipnh97rsE_3PFmPRs4zaVcejXqFklK6VaWbXZys5WCD7GgINegp1NOGlG9YZfjzrj1xv-Tcr4c-bVpf3azdj_TfzhnQ1vzwbMSx4tBh0h7w_Y28wi6d7b_7Z_908aJussmOkHnjCO-T4u09NMR66p_rrdfzs_E5RWvBbiNztQrVE</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Schnepf, Nathalie</creator><creator>Dhédin, Nathalie</creator><creator>Mercier-Delarue, Séverine</creator><creator>Andreoli, Annalisa</creator><creator>Mamez, Anne-Claire</creator><creator>Ferry, Christelle</creator><creator>Deback, Claire</creator><creator>Ribaud, Patricia</creator><creator>Robin, Marie</creator><creator>Socié, Gérard</creator><creator>Simon, François</creator><creator>Mazeron, Marie-Christine</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201312</creationdate><title>Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient</title><author>Schnepf, Nathalie ; Dhédin, Nathalie ; Mercier-Delarue, Séverine ; Andreoli, Annalisa ; Mamez, Anne-Claire ; Ferry, Christelle ; Deback, Claire ; Ribaud, Patricia ; Robin, Marie ; Socié, Gérard ; Simon, François ; Mazeron, Marie-Christine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-a2fa0adb4f2e8ee9be5128e08c4068d32c86bd1c3f22c2326a3cd3c91c16bd6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - genetics</topic><topic>Cytomegalovirus Infections - drug therapy</topic><topic>Cytomegalovirus Infections - virology</topic><topic>Drug Resistance, Viral - genetics</topic><topic>Female</topic><topic>Genes, Viral</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Kinetics</topic><topic>Mutation</topic><topic>Resistance</topic><topic>Stem cell transplantation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schnepf, Nathalie</creatorcontrib><creatorcontrib>Dhédin, Nathalie</creatorcontrib><creatorcontrib>Mercier-Delarue, Séverine</creatorcontrib><creatorcontrib>Andreoli, Annalisa</creatorcontrib><creatorcontrib>Mamez, Anne-Claire</creatorcontrib><creatorcontrib>Ferry, Christelle</creatorcontrib><creatorcontrib>Deback, Claire</creatorcontrib><creatorcontrib>Ribaud, Patricia</creatorcontrib><creatorcontrib>Robin, Marie</creatorcontrib><creatorcontrib>Socié, Gérard</creatorcontrib><creatorcontrib>Simon, François</creatorcontrib><creatorcontrib>Mazeron, Marie-Christine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schnepf, Nathalie</au><au>Dhédin, Nathalie</au><au>Mercier-Delarue, Séverine</au><au>Andreoli, Annalisa</au><au>Mamez, Anne-Claire</au><au>Ferry, Christelle</au><au>Deback, Claire</au><au>Ribaud, Patricia</au><au>Robin, Marie</au><au>Socié, Gérard</au><au>Simon, François</au><au>Mazeron, Marie-Christine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient</atitle><jtitle>Journal of clinical virology</jtitle><addtitle>J Clin Virol</addtitle><date>2013-12</date><risdate>2013</risdate><volume>58</volume><issue>4</issue><spage>733</spage><epage>736</epage><pages>733-736</pages><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>Abstract We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Allergy and Immunology Antiviral Agents - therapeutic use Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus Infections - drug therapy Cytomegalovirus Infections - virology Drug Resistance, Viral - genetics Female Genes, Viral Hematopoietic Stem Cell Transplantation Humans Infectious Disease Kinetics Mutation Resistance Stem cell transplantation Young Adult |
| title | Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient |
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