Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient

Abstract We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depe...

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Veröffentlicht in:	Journal of clinical virology 2013-12, Vol.58 (4), p.733-736
Hauptverfasser:	Schnepf, Nathalie, Dhédin, Nathalie, Mercier-Delarue, Séverine, Andreoli, Annalisa, Mamez, Anne-Claire, Ferry, Christelle, Deback, Claire, Ribaud, Patricia, Robin, Marie, Socié, Gérard, Simon, François, Mazeron, Marie-Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Antiviral Agents - therapeutic use Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus Infections - drug therapy Cytomegalovirus Infections - virology Drug Resistance, Viral - genetics Female Genes, Viral Hematopoietic Stem Cell Transplantation Humans Infectious Disease Kinetics Mutation Resistance Stem cell transplantation Young Adult
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Zusammenfassung:	Abstract We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depend on both the selection pressure exerted by the antiviral treatments and the immune response.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2013.10.007