Successful treatment of a mycophenolate mofetil-refractory proliferative lupus nephritis with Belimumab in a 19-year-old woman

We report the case of a 19-year-old woman with progressive proliferative lupus nephritis (LN) class III after induction and maintenance therapy with mycophenolate mofetil (MMF). Despite a satisfying clinical improvement proteinuria progressed under this medication. We treated the patient with additi...

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Veröffentlicht in:Lupus 2013-12, Vol.22 (14), p.1523-1525
Hauptverfasser: Fließer, EE, Korsten, P, Koziolek, MJ, Niewold, TB, Patschan, D, Müller, GA, Patschan, SA
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Sprache:eng
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Zusammenfassung:We report the case of a 19-year-old woman with progressive proliferative lupus nephritis (LN) class III after induction and maintenance therapy with mycophenolate mofetil (MMF). Despite a satisfying clinical improvement proteinuria progressed under this medication. We treated the patient with additional belimumab after discussing other options. Following treatment with belimumab, proteinuria rapidly improved to almost normal levels and clinical remission lasted. Belimumab might hold promise for this indication.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203313504145