TGF-β1 Attenuates Spinal Neuroinflammation and the Excitatory Amino Acid System in Rats With Neuropathic Pain

Abstract Previous studies have reported that the intrathecal (i.t.) administration of transforming growth factor β1 (TGF-β1) prevents and reverses neuropathic pain. However, only limited information is available regarding the possible role and effects of spinal TGF-β1 in neuropathic pain. We aimed t...

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Veröffentlicht in:	The journal of pain 2013-12, Vol.14 (12), p.1671-1685
Hauptverfasser:	Chen, Nan-Fu, Huang, Shi-Ying, Chen, Wu-Fu, Chen, Chun-Hong, Lu, Ching-Hsiang, Chen, Chun-Lin, Yang, San-Nan, Wang, Hui-Min, Wen, Zhi-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia & Perioperative Care Animals Astrocytes - metabolism Astrocytes - pathology chronic constriction injury Down-Regulation - physiology excitatory amino acids Excitatory Amino Acids - antagonists & inhibitors Excitatory Amino Acids - metabolism glutamate transporters Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Injections, Spinal Male Microglia - metabolism Microglia - pathology Neuralgia - metabolism Neuralgia - pathology Neuralgia - prevention & control Pain Medicine Rats Rats, Wistar Sciatic Neuropathy - metabolism Sciatic Neuropathy - pathology Sciatic Neuropathy - prevention & control Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology Transforming Growth Factor beta1 - administration & dosage Transforming Growth Factor beta1 - metabolism Transforming growth factor-β1 Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis tumor necrosis factor-α
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