Interactive effects of mechanical ventilation, inhaled nitric oxide and oxidative stress in acute lung injury

Interactive effects of mechanical ventilation, inhaled nitric oxide and oxidative stress in acute lung injury

Highlights • Oxidative damage has been said to play an important role in pulmonary injury. • High-frequency ventilation has a protective effect against oxidative lung injury. • Lung injury can be induced by conventional mechanical ventilation. • Conventional mechanical ventilation with inhaled nitri...

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Veröffentlicht in:Respiratory physiology & neurobiology 2014-01, Vol.190, p.118-123
Hauptverfasser: Ronchi, Carlos Fernando, Ferreira, Ana Lucia Anjos, Campos, Fabio Joly, Kurokawa, Cilmery Suemi, Carpi, Mario Ferreira, Moraes, Marcos Aurélio, Bonatto, Rossano Cesar, Yeum, Kyung-Jin, Fioretto, Jose Roberto
Format: Artikel
Sprache:eng
Schlagworte:
Acute Lung Injury - pathology
Acute Lung Injury - physiopathology
Acute Lung Injury - therapy
Administration, Inhalation
Animals
Bronchodilator Agents - administration & dosage
Cell Count
Conventional mechanical ventilation
Disease Models, Animal
DNA damage
DNA Damage - drug effects
Dose-Response Relationship, Drug
High-frequency oscillatory ventilation
Inhaled nitric oxide
Lung - drug effects
Lung - metabolism
Lung - pathology
Male
Medical Education
Nitrates - blood
Nitric Oxide - administration & dosage
Nitrites - blood
Oxidative Stress - drug effects
Pulmonary Gas Exchange - drug effects
Pulmonary Gas Exchange - physiology
Pulmonary oxidative stress
Pulmonary/Respiratory
Rabbits
Respiration, Artificial
Time Factors
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Zusammenfassung:Highlights • Oxidative damage has been said to play an important role in pulmonary injury. • High-frequency ventilation has a protective effect against oxidative lung injury. • Lung injury can be induced by conventional mechanical ventilation. • Conventional mechanical ventilation with inhaled nitric oxide reduces DNA damage.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2013.10.008