Severely reduced diffusion capacity in idiopathic pulmonary arterial hypertension: patient characteristics and treatment responses

A subgroup of patients with idiopathic pulmonary arterial hypertension (IPAH) has severely reduced diffusing capacity of the lung for carbon monoxide (DLCO) and poor prognosis. Their characteristics are currently unknown. The aim of this study is to contrast clinical characteristics and treatment re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The European respiratory journal 2013-12, Vol.42 (6), p.1575-1585
Hauptverfasser:	TRIP, Pia, NOSSENT, Esther J, VONK-NOORDEGRAAF, Anton, DE MAN, Frances S, VAN DEN BERK, Inge A. H, BOONSTRA, Anco, GROEPENHOFF, Herman, LETER, Edward M, WESTERHOF, Nico, GRÜNBERG, Katrien, BOGAARD, Harm-Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Carbon Monoxide - chemistry Coronary Artery Disease - complications Familial Primary Pulmonary Hypertension Female Forced Expiratory Volume Humans Hypertension, Pulmonary - physiopathology Hypertension, Pulmonary - therapy Lung - physiopathology Male Medical sciences Middle Aged Pneumology Prognosis Pulmonary Alveoli - physiology Pulmonary Diffusing Capacity Pulmonary Fibrosis - pathology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Retrospective Studies Smoking - adverse effects Tomography, X-Ray Computed Total Lung Capacity Treatment Outcome Vital Capacity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A subgroup of patients with idiopathic pulmonary arterial hypertension (IPAH) has severely reduced diffusing capacity of the lung for carbon monoxide (DLCO) and poor prognosis. Their characteristics are currently unknown. The aim of this study is to contrast clinical characteristics and treatment responses of IPAH-patients with a severely reduced and more preserved DLCO. Retrospectively, 166 IPAH patients were included and grouped based on a DLCO cut-off value of 45% pred (IPAH(
ISSN:	0903-1936 1399-3003
DOI:	10.1183/09031936.00184412