The family of human Na super(+),K super(+)-ATPase genes. A partial nucleotide sequence related to the alpha -subunit

The family of human Na super(+),K super(+)-ATPase genes. A partial nucleotide sequence related to the alpha -subunit

The Na super(+),K super(+)-activated adenosine triphosphatase (EC 3.6.1.3) localized in animal cell membranes represents a universal system for the active transport of Na super(+) and K super(+). In order to elucidate the molecular mechanism of the active cation transport we have analysed the struct...

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Veröffentlicht in:FEBS letters 1987-01, Vol.213 (1), p.73-80
Hauptverfasser: Ovchinnikov, YA, Monastyrskaya, G S, Broude, N E, Allikmets, R L, Ushkaryov, YA, Melkov, A M, Smirnov, Y V, Malyshev, I V, Dulubova, I E
Format: Artikel
Sprache:eng
Schlagworte:
adenosinetriphosphatase
amino acid sequence
cDNA
gene families
genes
man
nucleotide sequence
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Zusammenfassung:The Na super(+),K super(+)-activated adenosine triphosphatase (EC 3.6.1.3) localized in animal cell membranes represents a universal system for the active transport of Na super(+) and K super(+). In order to elucidate the molecular mechanism of the active cation transport we have analysed the structural organization of the enzyme from several species. The complete nucleotide sequences of cDNA clones corresponding to the coding regions of appropriate mRNAs were determined, and the primary structure of the alpha - and beta -subunits of the pig kidney Na super(+),K super(+)-ATPase could then be deduced (1-3).
ISSN:0014-5793