Manganese intakes in intravenously fed infants: Dosages and toxicity studies

Manganese is recommended for inclusion in total parental nutrition (TPN) regimens, although Mn deficiency has never been documented in humans, and toxicity is well described. To determine the intravenous (iv) Mn intakes required to build up body stores in the preterm infant and achieve positive rete...

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Veröffentlicht in:	Biological trace element research 1986-05, Vol.9 (4), p.271-280
Hauptverfasser:	Zlotkin, Stanley H., Buchanan, Barbara E.
Format:	Artikel
Sprache:	eng
Schlagworte:	absorcion de substancias nutritivas absorption de substances nutritives alimentacion alimentation feeding infantes infants manganese manganeso nouveau ne nutrient uptake toxicidad toxicite toxicity
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description	Manganese is recommended for inclusion in total parental nutrition (TPN) regimens, although Mn deficiency has never been documented in humans, and toxicity is well described. To determine the intravenous (iv) Mn intakes required to build up body stores in the preterm infant and achieve positive retention in full-term infants and to identify and quantify the biochemical changes that may predate frank Mn toxicity, short-term balance studies were completed in 24 preterm and full-term infants. Preterm infants receiving intakes of Mn at 9 mu g/kg/d achieve in utero retention rates. Biochemical evidence of Mn toxicity was not apparent, even at the highest doses provided.
doi_str_mv	10.1007/BF02988825
format	Article
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To determine the intravenous (iv) Mn intakes required to build up body stores in the preterm infant and achieve positive retention in full-term infants and to identify and quantify the biochemical changes that may predate frank Mn toxicity, short-term balance studies were completed in 24 preterm and full-term infants. Preterm infants receiving intakes of Mn at 9 mu g/kg/d achieve in utero retention rates. Biochemical evidence of Mn toxicity was not apparent, even at the highest doses provided.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/BF02988825</identifier><language>eng</language><subject>absorcion de substancias nutritivas ; absorption de substances nutritives ; alimentacion ; alimentation ; feeding ; infantes ; infants ; manganese ; manganeso ; nouveau ne ; nutrient uptake ; toxicidad ; toxicite ; toxicity</subject><ispartof>Biological trace element research, 1986-05, Vol.9 (4), p.271-280</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c242t-6bbf42ca2c4c78953217ad05c958fd0db6a4b19c7de7e5334749935fa21d36223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Zlotkin, Stanley H.</creatorcontrib><creatorcontrib>Buchanan, Barbara E.</creatorcontrib><title>Manganese intakes in intravenously fed infants: Dosages and toxicity studies</title><title>Biological trace element research</title><description>Manganese is recommended for inclusion in total parental nutrition (TPN) regimens, although Mn deficiency has never been documented in humans, and toxicity is well described. 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Biochemical evidence of Mn toxicity was not apparent, even at the highest doses provided.</description><subject>absorcion de substancias nutritivas</subject><subject>absorption de substances nutritives</subject><subject>alimentacion</subject><subject>alimentation</subject><subject>feeding</subject><subject>infantes</subject><subject>infants</subject><subject>manganese</subject><subject>manganeso</subject><subject>nouveau ne</subject><subject>nutrient uptake</subject><subject>toxicidad</subject><subject>toxicite</subject><subject>toxicity</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNpFkE1Lw0AQhhdRsFYv_gDJyYMQ3c9s1ptWq0LFg_a8TPajRNOkZlJp_71bKnh6h-HhZeYh5JzRa0apvrmfUm7KsuTqgIyYUianmtNDMqKsELk0pTwmJ4iflDLNjRiR2Su0C2gDhqxuB_gKmHI39vAT2m6NzTaLwadNhHbA2-yhQ1gkClqfDd2mdvWwzXBY-zrgKTmK0GA4-8sxmU8fPybP-ezt6WVyN8sdl3zIi6qKkjvgTjpdGiU40-CpckaV0VNfFSArZpz2QQclhNTSGKEicOZFwbkYk8t976rvvtcBB7us0YWmSY-kky2ThRBJRwKv9qDrO8Q-RLvq6yX0W8uo3Qmz_8ISfLGHI3QWFn2Ndv7OTKkpFUUhpPgFN81mcQ</recordid><startdate>19860501</startdate><enddate>19860501</enddate><creator>Zlotkin, Stanley H.</creator><creator>Buchanan, Barbara E.</creator><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19860501</creationdate><title>Manganese intakes in intravenously fed infants: Dosages and toxicity studies</title><author>Zlotkin, Stanley H. ; Buchanan, Barbara E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c242t-6bbf42ca2c4c78953217ad05c958fd0db6a4b19c7de7e5334749935fa21d36223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>absorcion de substancias nutritivas</topic><topic>absorption de substances nutritives</topic><topic>alimentacion</topic><topic>alimentation</topic><topic>feeding</topic><topic>infantes</topic><topic>infants</topic><topic>manganese</topic><topic>manganeso</topic><topic>nouveau ne</topic><topic>nutrient uptake</topic><topic>toxicidad</topic><topic>toxicite</topic><topic>toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zlotkin, Stanley H.</creatorcontrib><creatorcontrib>Buchanan, Barbara E.</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zlotkin, Stanley H.</au><au>Buchanan, Barbara E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manganese intakes in intravenously fed infants: Dosages and toxicity studies</atitle><jtitle>Biological trace element research</jtitle><date>1986-05-01</date><risdate>1986</risdate><volume>9</volume><issue>4</issue><spage>271</spage><epage>280</epage><pages>271-280</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Manganese is recommended for inclusion in total parental nutrition (TPN) regimens, although Mn deficiency has never been documented in humans, and toxicity is well described. To determine the intravenous (iv) Mn intakes required to build up body stores in the preterm infant and achieve positive retention in full-term infants and to identify and quantify the biochemical changes that may predate frank Mn toxicity, short-term balance studies were completed in 24 preterm and full-term infants. Preterm infants receiving intakes of Mn at 9 mu g/kg/d achieve in utero retention rates. Biochemical evidence of Mn toxicity was not apparent, even at the highest doses provided.</abstract><doi>10.1007/BF02988825</doi><tpages>10</tpages></addata></record>
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source	Springer Nature - Complete Springer Journals
subjects	absorcion de substancias nutritivas absorption de substances nutritives alimentacion alimentation feeding infantes infants manganese manganeso nouveau ne nutrient uptake toxicidad toxicite toxicity
title	Manganese intakes in intravenously fed infants: Dosages and toxicity studies
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