Epithelial membrane protein 3 is frequently shown as promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer
Epithelial membrane protein 3 (EMP3) is a typical member of the epithelial membrane protein (EMP) family which has been reported to be a tumor suppressor gene in neuroblastomas and gliomas and recently reported to be commonly repressed in esophageal squamous cell carcinoma (ESCC) cell lines. However...
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| Veröffentlicht in: | Experimental and molecular pathology 2013-12, Vol.95 (3), p.313-318 |
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| creator | Xue, Qun Zhou, Yiqun Wan, Chunhua Lv, Liting Chen, Buyou Cao, Xiang Ju, Guanjun Huang, Yuexia Ni, Runzhou Mao, Guoxin |
| description | Epithelial membrane protein 3 (EMP3) is a typical member of the epithelial membrane protein (EMP) family which has been reported to be a tumor suppressor gene in neuroblastomas and gliomas and recently reported to be commonly repressed in esophageal squamous cell carcinoma (ESCC) cell lines. However, the expression and clinical significance of EMP3 protein in lung cancer have not yet been elucidated. In this article, we detected that the expression of EMP3 in non-small cell lung cancer was significantly lower than the expression of normal lung tissues (P |
| doi_str_mv | 10.1016/j.yexmp.2013.07.001 |
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[Display omitted]
•The expression of EMP3 in non-small cell lung cancer was significantly lower than the expression of normal lung tissues.•EMP3 expression in non-small cell Lung cancer was significantly related to p-TNM stage and EMP3 was negatively correlated with proliferation marker Ki67.•The post-recurrent survival after radical surgery was poorer in lung cancer patients with lower EMP3 expression.</description><identifier>ISSN: 0014-4800</identifier><identifier>EISSN: 1096-0945</identifier><identifier>DOI: 10.1016/j.yexmp.2013.07.001</identifier><identifier>PMID: 23920144</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adult ; Aged ; Blotting, Western ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Cell Cycle ; Cell Proliferation ; DNA Methylation ; EMP3 ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunoenzyme Techniques ; Lung - metabolism ; Lung - pathology ; Lung cancer ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Male ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - metabolism ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Promoter Regions, Genetic - genetics ; Survival Rate ; Tumor Cells, Cultured ; Tumor suppressor gene</subject><ispartof>Experimental and molecular pathology, 2013-12, Vol.95 (3), p.313-318</ispartof><rights>2013 Elsevier Inc.</rights><rights>2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-89f00cb82cf2e18ef330934aa4af0d052b62f23ccaf37c99f65ea693b0620f963</citedby><cites>FETCH-LOGICAL-c425t-89f00cb82cf2e18ef330934aa4af0d052b62f23ccaf37c99f65ea693b0620f963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014480013000877$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23920144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Qun</creatorcontrib><creatorcontrib>Zhou, Yiqun</creatorcontrib><creatorcontrib>Wan, Chunhua</creatorcontrib><creatorcontrib>Lv, Liting</creatorcontrib><creatorcontrib>Chen, Buyou</creatorcontrib><creatorcontrib>Cao, Xiang</creatorcontrib><creatorcontrib>Ju, Guanjun</creatorcontrib><creatorcontrib>Huang, Yuexia</creatorcontrib><creatorcontrib>Ni, Runzhou</creatorcontrib><creatorcontrib>Mao, Guoxin</creatorcontrib><title>Epithelial membrane protein 3 is frequently shown as promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer</title><title>Experimental and molecular pathology</title><addtitle>Exp Mol Pathol</addtitle><description>Epithelial membrane protein 3 (EMP3) is a typical member of the epithelial membrane protein (EMP) family which has been reported to be a tumor suppressor gene in neuroblastomas and gliomas and recently reported to be commonly repressed in esophageal squamous cell carcinoma (ESCC) cell lines. However, the expression and clinical significance of EMP3 protein in lung cancer have not yet been elucidated. In this article, we detected that the expression of EMP3 in non-small cell lung cancer was significantly lower than the expression of normal lung tissues (P<0.01) by western blot. EMP3 expression in Lung cancer was significantly related to p-TNM stage (P<0.05) and EMP3 was negatively correlated with proliferation marker Ki67(r=−0.775; P<0.01), However, no significant correlations were found between EMP3 and other clinical parameters. The post-recurrent survival after radical surgery was poorer in lung cancer patients with lower EMP3 expression (P<0.01). While in vitro, following release from serum starvation of A549 NSCLC cell, the expression of EMP3 was deregulated. Thus, our finding suggests that EMP3 may be a tumor suppressor gene at the late step of lung cancer, and EMP3 may be a potential prognostic marker and therapeutic target of NSCLC.
[Display omitted]
•The expression of EMP3 in non-small cell lung cancer was significantly lower than the expression of normal lung tissues.•EMP3 expression in non-small cell Lung cancer was significantly related to p-TNM stage and EMP3 was negatively correlated with proliferation marker Ki67.•The post-recurrent survival after radical surgery was poorer in lung cancer patients with lower EMP3 expression.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Blotting, Western</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Cycle</subject><subject>Cell Proliferation</subject><subject>DNA Methylation</subject><subject>EMP3</subject><subject>Epigenesis, Genetic</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Survival Rate</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor suppressor gene</subject><issn>0014-4800</issn><issn>1096-0945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi1ERZfCL0BCPnJJGH9sEh84oKp8SJV6KWfLccZdr2In2Amw_6I_GYctHLnYntHzznjeIeQNg5oBa94f6xP-CnPNgYka2hqAPSM7BqqpQMn9c7IrGVnJDuCSvMz5CAAKGH9BLrlQRSXljjzezH454OjNSAOGPpmIdE7Tgj5SQX2mLuH3FeMynmg-TD8jNXkDQkFSkSyH02gWP5V8HKhbo92CvFGGLmuYEs3rPCfMuTwfsJQvleMUqxzMOFKL5RjX-ECtiRbTK3LhzJjx9dN9Rb59urm__lLd3n3-ev3xtrKS75eqUw7A9h23jiPr0AkBSkhjpHEwwJ73DXdcWGucaK1SrtmjaZTooeHgVCOuyLtz3TJLmS8vOvi8faYYMK1ZM9nwtpFdu6HijNo05ZzQ6Tn5YNJJM9DbKvRR_1mF3lahodXF-KJ6-9Rg7QMO_zR_vS_AhzOAZcwfHpPO1mPxYPAJ7aKHyf-3wW-Ksp6n</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Xue, Qun</creator><creator>Zhou, Yiqun</creator><creator>Wan, Chunhua</creator><creator>Lv, Liting</creator><creator>Chen, Buyou</creator><creator>Cao, Xiang</creator><creator>Ju, Guanjun</creator><creator>Huang, Yuexia</creator><creator>Ni, Runzhou</creator><creator>Mao, Guoxin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>Epithelial membrane protein 3 is frequently shown as promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer</title><author>Xue, Qun ; Zhou, Yiqun ; Wan, Chunhua ; Lv, Liting ; Chen, Buyou ; Cao, Xiang ; Ju, Guanjun ; Huang, Yuexia ; Ni, Runzhou ; Mao, Guoxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-89f00cb82cf2e18ef330934aa4af0d052b62f23ccaf37c99f65ea693b0620f963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Blotting, Western</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Cycle</topic><topic>Cell Proliferation</topic><topic>DNA Methylation</topic><topic>EMP3</topic><topic>Epigenesis, Genetic</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Survival Rate</topic><topic>Tumor Cells, Cultured</topic><topic>Tumor suppressor gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Qun</creatorcontrib><creatorcontrib>Zhou, Yiqun</creatorcontrib><creatorcontrib>Wan, Chunhua</creatorcontrib><creatorcontrib>Lv, Liting</creatorcontrib><creatorcontrib>Chen, Buyou</creatorcontrib><creatorcontrib>Cao, Xiang</creatorcontrib><creatorcontrib>Ju, Guanjun</creatorcontrib><creatorcontrib>Huang, Yuexia</creatorcontrib><creatorcontrib>Ni, Runzhou</creatorcontrib><creatorcontrib>Mao, Guoxin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and molecular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Qun</au><au>Zhou, Yiqun</au><au>Wan, Chunhua</au><au>Lv, Liting</au><au>Chen, Buyou</au><au>Cao, Xiang</au><au>Ju, Guanjun</au><au>Huang, Yuexia</au><au>Ni, Runzhou</au><au>Mao, Guoxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epithelial membrane protein 3 is frequently shown as promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer</atitle><jtitle>Experimental and molecular pathology</jtitle><addtitle>Exp Mol Pathol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>95</volume><issue>3</issue><spage>313</spage><epage>318</epage><pages>313-318</pages><issn>0014-4800</issn><eissn>1096-0945</eissn><abstract>Epithelial membrane protein 3 (EMP3) is a typical member of the epithelial membrane protein (EMP) family which has been reported to be a tumor suppressor gene in neuroblastomas and gliomas and recently reported to be commonly repressed in esophageal squamous cell carcinoma (ESCC) cell lines. However, the expression and clinical significance of EMP3 protein in lung cancer have not yet been elucidated. In this article, we detected that the expression of EMP3 in non-small cell lung cancer was significantly lower than the expression of normal lung tissues (P<0.01) by western blot. EMP3 expression in Lung cancer was significantly related to p-TNM stage (P<0.05) and EMP3 was negatively correlated with proliferation marker Ki67(r=−0.775; P<0.01), However, no significant correlations were found between EMP3 and other clinical parameters. The post-recurrent survival after radical surgery was poorer in lung cancer patients with lower EMP3 expression (P<0.01). While in vitro, following release from serum starvation of A549 NSCLC cell, the expression of EMP3 was deregulated. Thus, our finding suggests that EMP3 may be a tumor suppressor gene at the late step of lung cancer, and EMP3 may be a potential prognostic marker and therapeutic target of NSCLC.
[Display omitted]
•The expression of EMP3 in non-small cell lung cancer was significantly lower than the expression of normal lung tissues.•EMP3 expression in non-small cell Lung cancer was significantly related to p-TNM stage and EMP3 was negatively correlated with proliferation marker Ki67.•The post-recurrent survival after radical surgery was poorer in lung cancer patients with lower EMP3 expression.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>23920144</pmid><doi>10.1016/j.yexmp.2013.07.001</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Blotting, Western Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell Cycle Cell Proliferation DNA Methylation EMP3 Epigenesis, Genetic Female Gene Expression Regulation, Neoplastic Humans Immunoenzyme Techniques Lung - metabolism Lung - pathology Lung cancer Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Middle Aged Neoplasm Grading Neoplasm Staging Prognosis Promoter Regions, Genetic - genetics Survival Rate Tumor Cells, Cultured Tumor suppressor gene |
| title | Epithelial membrane protein 3 is frequently shown as promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer |
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