Epithelial membrane protein 3 is frequently shown as promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer

Epithelial membrane protein 3 (EMP3) is a typical member of the epithelial membrane protein (EMP) family which has been reported to be a tumor suppressor gene in neuroblastomas and gliomas and recently reported to be commonly repressed in esophageal squamous cell carcinoma (ESCC) cell lines. However...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental and molecular pathology 2013-12, Vol.95 (3), p.313-318
Hauptverfasser:	Xue, Qun, Zhou, Yiqun, Wan, Chunhua, Lv, Liting, Chen, Buyou, Cao, Xiang, Ju, Guanjun, Huang, Yuexia, Ni, Runzhou, Mao, Guoxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Blotting, Western Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell Cycle Cell Proliferation DNA Methylation EMP3 Epigenesis, Genetic Female Gene Expression Regulation, Neoplastic Humans Immunoenzyme Techniques Lung - metabolism Lung - pathology Lung cancer Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Middle Aged Neoplasm Grading Neoplasm Staging Prognosis Promoter Regions, Genetic - genetics Survival Rate Tumor Cells, Cultured Tumor suppressor gene
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Epithelial membrane protein 3 (EMP3) is a typical member of the epithelial membrane protein (EMP) family which has been reported to be a tumor suppressor gene in neuroblastomas and gliomas and recently reported to be commonly repressed in esophageal squamous cell carcinoma (ESCC) cell lines. However, the expression and clinical significance of EMP3 protein in lung cancer have not yet been elucidated. In this article, we detected that the expression of EMP3 in non-small cell lung cancer was significantly lower than the expression of normal lung tissues (P
ISSN:	0014-4800 1096-0945
DOI:	10.1016/j.yexmp.2013.07.001