Pyridine derivatives, especially 2,6-di-tert-butylpyridine, labeled with nitrogen-15

Pyridine derivatives labeled with 15N can be prepared by the reaction of the corresponding pyrylium salts with 15NH4Cl in close to a stoichiometric ratio, in a sodium acetate–acetic acid buffer. In particular, the reaction of 2,6‐di‐tert‐butylpyrylium perchlorate gave 2,6‐di‐tert‐butylpyridine with a conversion of 95%. The compound is valuable for studies of acid–base interactions on solid acid catalysts by 15N nuclear magnetic resonance. Pyridine derivatives labeled with 15N can be prepared by the reaction of the corresponding pyrylium salts with 15NH4Cl in close to a stoichiometric ratio, in a sodium acetate–acetic acid buffer.