Role of NF-κB-Dependent Signaling in the Realization of Growth Potential of Mesenchymal Progenitor Cells in Vitro

Role of NF-κB-Dependent Signaling in the Realization of Growth Potential of Mesenchymal Progenitor Cells in Vitro

Signal pathways of realization of growth potential of mesenchymal progenitor cells related to transcription factor NF-κB were studied in vitro . NF-κB was found to participate in the proliferation and differentiation of progenitor elements that can be blocked by its specific inhibitor oridonin. NF-κ...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2013-10, Vol.155 (6), p.721-723
Hauptverfasser: Zyuz’kov, G. N., Danilets, M. G., Ligacheva, A. A., Zhdanov, V. V., Udut, E. V., Miroshnichenko, L. A., Simanina, E. V., Trofimova, E. S., Minakova, M. Yu, Chaikovskii, A. V., Agafonov, V. I., Dygai, A. M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Differentiation
Cell Proliferation
Cells, Cultured
Growth
Internal Medicine
Laboratory Medicine
Male
Mesenchymal Stem Cells - physiology
Mice
Mice, Inbred CBA
NF-kappa B - metabolism
Pathology
Signal Transduction
Stem cells
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Zusammenfassung:Signal pathways of realization of growth potential of mesenchymal progenitor cells related to transcription factor NF-κB were studied in vitro . NF-κB was found to participate in the proliferation and differentiation of progenitor elements that can be blocked by its specific inhibitor oridonin. NF-κB inhibitor aurothiomalate had no effect on the functions of fibroblastic CFU.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2236-8