SIBLING proteins: molecular tools for tumor progression and angiogenesis

The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin (OPN), bonesialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). These proteins, initially identified in bone and teet...

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Veröffentlicht in:	M.S. Médecine sciences 2013-11, Vol.29 (11), p.1018-1025
Hauptverfasser:	Lamour, Virginie, Nokin, Marie-Julie, Henry, Aurélie, Castronovo, Vincent, Bellahcène, Akeila
Format:	Artikel
Sprache:	fre
Schlagworte:	Animals Carcinogenesis Cell Adhesion Cell Movement Cell Proliferation Extracellular Matrix Proteins - physiology Glycoproteins - physiology Humans Integrin-Binding Sialoprotein - blood Integrin-Binding Sialoprotein - physiology Neoplasm Invasiveness Neoplasm Metastasis Neoplasms - pathology Neovascularization, Pathologic Osteopontin - physiology Phosphoproteins - physiology Sialoglycoproteins - physiology
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Beschreibung
Zusammenfassung:	The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin (OPN), bonesialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). These proteins, initially identified in bone and teeth, share many structural characteristics. It is now well established that they are over expressed in many tumors and play a critical role at different steps of cancer development. In this review, we describe the roles of SIBLING proteins at different stages of cancer progression including cancer cell adhesion, proliferation, migration, invasion, metastasis and angiogenesis.
ISSN:	0767-0974
DOI:	10.1051/medsci/20132911019