Predictive and prognostic factors in locally advanced breast cancer: effect of intratumoral FOXP3+ Tregs

This study aimed to investigate the prognostic and predictive effect of FOXP3+ Tregs together with clinicopathologic factors in locally advanced breast cancer (LABC) patients. The medical records of 101 LABC patients who received neoadjuvant chemotherapy (NAC) between 2005 and 2012 were evaluated re...

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Veröffentlicht in:	Clinical & experimental metastasis 2013-12, Vol.30 (8), p.1047-1062
Hauptverfasser:	Demir, Lutfiye, Yigit, Seyran, Ellidokuz, Hulya, Erten, Cigdem, Somali, Isil, Kucukzeybek, Yuksel, Alacacioglu, Ahmet, Cokmert, Suna, Can, Alper, Akyol, Murat, Dirican, Ahmet, Bayoglu, Vedat, Sari, Aysegul Akder, Tarhan, Mustafa Oktay
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Mucinous - drug therapy Adenocarcinoma, Mucinous - immunology Adenocarcinoma, Mucinous - mortality Adenocarcinoma, Mucinous - secondary Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Axilla Biomedical and Life Sciences Biomedicine Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Research Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - immunology Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - secondary Carcinoma, Lobular - drug therapy Carcinoma, Lobular - immunology Carcinoma, Lobular - mortality Carcinoma, Lobular - secondary Carcinoma, Papillary - drug therapy Carcinoma, Papillary - immunology Carcinoma, Papillary - mortality Carcinoma, Papillary - secondary Female Follow-Up Studies Forkhead Transcription Factors - metabolism Hematology Humans Immunoenzyme Techniques Lymphatic Metastasis Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Middle Aged Neoadjuvant Therapy Neoplasm Grading Neoplasm Staging Oncology Prognosis Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Research Paper Risk Factors Surgical Oncology Survival Rate T-Lymphocytes, Regulatory - immunology
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Zusammenfassung:	This study aimed to investigate the prognostic and predictive effect of FOXP3+ Tregs together with clinicopathologic factors in locally advanced breast cancer (LABC) patients. The medical records of 101 LABC patients who received neoadjuvant chemotherapy (NAC) between 2005 and 2012 were evaluated retrospectively. The density of intratumoral FOXP3+ lymphocytes in paraffin-embedded tissues was assessed by immunohistochemical analyses in appropriate cases. The relationship with clinicopathologic features, prognosis and chemotherapy response was investigated. HR(–) and HER2(+) tumors tended to have higher pre-chemotherapy Tregs than HR(+) tumors, and significantly higher pathologic complete response (PCR) rates were observed in these patients. Treg decline after NAC was associated with better pathological response rates. Lower intratumoral infiltration of FOXP3+ Tregs after NAC (
ISSN:	0262-0898 1573-7276
DOI:	10.1007/s10585-013-9602-9