De novo design of functional proteins: Toward artificial hydrogenases

ABSTRACT Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well‐folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustain...

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Veröffentlicht in:Biopolymers 2013-11, Vol.100 (6), p.558-571
Hauptverfasser: Faiella, Marina, Roy, Anindya, Sommer, Dayn, Ghirlanda, Giovanna
Format: Artikel
Sprache:eng
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Zusammenfassung:ABSTRACT Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well‐folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustainable fuel production. This review surveys recent examples of bioinspired de novo designed peptide based catalysts, focusing in particular on artificial hydrogenases. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 558–571, 2013.
ISSN:0006-3525
2475-8817
1097-0282
2475-8817
DOI:10.1002/bip.22420