Inhibition of arm regeneration by Ophioderma brevispina (echinodermata, ophiuroidea) by tributyltin oxide and triphenyltin oxide

Effects of water-bourne toxicants on regeneration of arms by the brittle star, Ophioderma brevispina, are described. Regeneration was inhibited by 0.1 μg liter −1 bis(tri- n-butyltin)oxide and bis(triphenyltin)oxide. Both substances are known to act upon the nervous system, and it is suggested that inhibition was caused by neurotoxicological action of the tin compounds or by their direct effect upon tissue at the breakage point. The former is most likely because regeneration is mediated by the radial nerves of brittle stars.