Effects of formaldehyde exposure on human NK cells in vitro

Effects of formaldehyde exposure on human NK cells in vitro

Highlights • Formaldehyde had a distinct toxicity on human NK cells. • The minimum concentration of formaldehyde to induce toxicity was 800 μM. • Formaldehyde can inhibit the adhering and cytotoxicity of NK cells. • Formaldehyde can reduce the viability and perforin secretion of NK cells.

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Bibliographische Detailangaben
Veröffentlicht in:Environmental toxicology and pharmacology 2013-11, Vol.36 (3), p.948-955
Hauptverfasser: Li, Qi, Mei, Qibing, Huyan, Ting, Xie, Li, Che, Su, Yang, Hui, Zhang, Mingjie, Huang, Qingsheng
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis - drug effects
Cell Survival - drug effects
Cells, Cultured
Cytokines - metabolism
Cytotoxicity
Emergency
Environmental Pollutants - toxicity
Formaldehyde
Formaldehyde - toxicity
Granzymes - metabolism
Humans
In vitro
Interferon-gamma - metabolism
Killer Cells, Natural - drug effects
Killer Cells, Natural - ultrastructure
Natural killer cell
Perforin - metabolism
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Beschreibung
Zusammenfassung:Highlights • Formaldehyde had a distinct toxicity on human NK cells. • The minimum concentration of formaldehyde to induce toxicity was 800 μM. • Formaldehyde can inhibit the adhering and cytotoxicity of NK cells. • Formaldehyde can reduce the viability and perforin secretion of NK cells.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2013.08.005