Effect of salicylate on the uptake of cefmetazole into brain of mice

Cefmetazole distribution into mice cerebral cortex was minimal when the drug was administered alone. However, the co-administration of salicylate or diethyl maleate enhanced cefmetazole uptake into the cerebral cortex, while it decreased the level of reduced nonprotein sulfhydryls in cerebral cortex. The enhanced cerebral uptake of cefmetazole was suppressed by the simultaneous administration of cysteamine with a concomitant recovery of the reduced nonprotein sulfhydryl concentration in cerebral cortex.