Hepatoprotective Prenylaromadendrane-Type Diterpenes from the Gum Resin of Boswellia carterii

Chemical examination of the exuded gum resin of Boswellia carterii resulted in the isolation of nine new prenylaromadendrane-type diterpenes, boscartols A–I (1–9). The structures of these compounds were established by extensive 1D and 2D NMR spectroscopic analyses, mass spectrometric data, and circu...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2013-11, Vol.76 (11), p.2074-2079
Hauptverfasser:	Wang, Yan-gai, Ren, Jin, Wang, Ai-guo, Yang, Jian-bo, Ji, Teng-fei, Ma, Qin-Ge, Tian, Jin, Su, Ya-lun
Format:	Artikel
Sprache:	eng
Schlagworte:	Boswellia - chemistry Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Galactosamine - pharmacology Gingiva - drug effects Humans Immunologic Factors Liver - drug effects Liver - metabolism Molecular Structure Nuclear Magnetic Resonance, Biomolecular Resins, Plant - chemistry Resins, Plant - pharmacology Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	Chemical examination of the exuded gum resin of Boswellia carterii resulted in the isolation of nine new prenylaromadendrane-type diterpenes, boscartols A–I (1–9). The structures of these compounds were established by extensive 1D and 2D NMR spectroscopic analyses, mass spectrometric data, and circular dichroism spectra. Compounds 1–3, 5, 6, 8, and 9 (10 μM) showed moderate hepatoprotective activity against d-galactosamine-induced HL-7702 cell damage.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np400526b