Copper-Catalyzed gem-Difluoroolefination of Diazo Compounds with TMSCF3 via C–F Bond Cleavage

A novel Cu-catalyzed gem-difluoroolefination of diazo compounds is described. This transformation starts from readily available TMSCF3 and diazo compounds, via trifluoromethylation followed by C–F bond cleavage, to afford the desired 1,1-difluoroalkene products.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2013-11, Vol.135 (46), p.17302-17305
Hauptverfasser:	Hu, Mingyou, He, Zhengbiao, Gao, Bing, Li, Lingchun, Ni, Chuanfa, Hu, Jinbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Azo Compounds - chemistry Catalysis Copper - chemistry Hydrocarbons, Fluorinated - chemical synthesis Hydrocarbons, Fluorinated - chemistry Molecular Structure Silanes - chemistry
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Beschreibung
Zusammenfassung:	A novel Cu-catalyzed gem-difluoroolefination of diazo compounds is described. This transformation starts from readily available TMSCF3 and diazo compounds, via trifluoromethylation followed by C–F bond cleavage, to afford the desired 1,1-difluoroalkene products.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja409941r