Inhibitory effects of calmodulin antagonists on urinary enzyme excretion in rats after nephrotoxic doses of mercuric chloride

Prochlorperazine, a phenothiazine antiemetic, has been reported to protect rats against mercuric chloride (HgCl sub(2))-induced nephrotoxicity. Mercuric ion and 12 other divalent metal ions of toxicologic importance inhibit the activity of calmodulin. Phenothiazines, including prochlorperazine, are...

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Veröffentlicht in:	Bull. Environ. Contam. Toxicol.; (United States) 1985-03, Vol.34 (3), p.432-437
Hauptverfasser:	HARRISON, S. D. JR, COX, J. L, GILES, R. C. JR
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) Acetylglucosaminidase - urine AMINE OXIDASES AMINES AMINOPEPTIDASES ANIMALS AZINES AZOLES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BIOLOGICAL WASTES BODY BODY FLUIDS Calmodulin - antagonists & inhibitors CENTRAL NERVOUS SYSTEM AGENTS CENTRAL NERVOUS SYSTEM DEPRESSANTS Chemical and industrial products toxicology. Toxic occupational diseases CHLORIDES CHLORINE COMPOUNDS CHLORPROMAZINE CLEARANCE CREATININE DRUGS ENZYME ACTIVITY ENZYMES EXCRETION HALIDES HALOGEN COMPOUNDS HETEROCYCLIC COMPOUNDS HYDROLASES HYPNOTICS AND SEDATIVES IMIDAZOLES IMINES INHIBITION Kidney - drug effects KIDNEYS Leucyl Aminopeptidase - urine MAMMALS MATERIALS Medical sciences Mercuric Chloride - toxicity MERCURY CHLORIDES MERCURY COMPOUNDS MERCURY HALIDES Metals and various inorganic compounds ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS ORGANS OXIDOREDUCTASES PEPTIDE HYDROLASES PHENOTHIAZINES Phenothiazines - pharmacology PSYCHOTROPIC DRUGS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS RECEPTORS Regression Analysis RODENTS TOXICITY Toxicology TRANQUILIZERS URINE VERTEBRATES WASTES
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Zusammenfassung:	Prochlorperazine, a phenothiazine antiemetic, has been reported to protect rats against mercuric chloride (HgCl sub(2))-induced nephrotoxicity. Mercuric ion and 12 other divalent metal ions of toxicologic importance inhibit the activity of calmodulin. Phenothiazines, including prochlorperazine, are reversible calmodulin antagonists, and as such they interact with divalent calcium at the level of calmodulin. It was of interest therefore to evaluate the comparative effects of several phenothiazines on HgCl sub(2)-induced nephrotoxicity in rats.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/BF01609757