Molecular profiling of EGFR family in chronic obstructive pulmonary disease: correlation with airway obstruction

Background Growth factors mediate various cellular responses to environmental stimuli. Specifically, exposure of lung epithelium to oxidative stress induced by cigarette smoke stimulates aberrant epidermal growth factor receptor (ERBB) family activation. This study's objective was to evaluate t...

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Veröffentlicht in:	European journal of clinical investigation 2013-12, Vol.43 (12), p.1299-1306
Hauptverfasser:	Anagnostis, Aristotelis, Neofytou, Eirini, Soulitzis, Nikolaos, Kampas, Dimitris, Drositis, Ioannis, Dermitzaki, Despina, Tzanakis, Nikolaos, Schiza, Sofia, Siafakas, Nikolaos M., Tzortzaki, Eleni G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Obstruction - metabolism Chronic obstructive pulmonary disease degree of airway obstruction DNA, Complementary - biosynthesis epidermal growth factor receptor Forced Expiratory Volume - physiology forced expiratory volume in first second Humans Lung - metabolism Male Microarray Analysis Middle Aged Pulmonary Disease, Chronic Obstructive - metabolism Real-Time Polymerase Chain Reaction Receptor, Epidermal Growth Factor - metabolism RNA - metabolism smoking Smoking - metabolism Vital Capacity - physiology
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