Molecular profiling of EGFR family in chronic obstructive pulmonary disease: correlation with airway obstruction

Background Growth factors mediate various cellular responses to environmental stimuli. Specifically, exposure of lung epithelium to oxidative stress induced by cigarette smoke stimulates aberrant epidermal growth factor receptor (ERBB) family activation. This study's objective was to evaluate the expression of ERBB1–4 receptors in the lung tissue of smokers with or without chronic obstructive pulmonary disease (COPD). Materials and methods ERBBs expression was measured by microarray analysis in lung tissue samples from five patients with COPD and five non‐COPD smokers, and by quantitative real‐time PCR in additional 20 patients with COPD (GOLD stage II), 15 non‐COPD smokers and 10 nonsmoker controls. Results Microarray data analysis revealed that ERBB receptors expression was elevated in patients with COPD compared to non‐COPD smokers, ranging from 1·62‐ to 2·45‐fold, (P