MiR-215 modulates gastric cancer cell proliferation by targeting RB1

Highlights • MiR-215 is frequently up-regulated in gastric cancer and may serve as a biomarker for diagnosis. • Inhibition of miR-215 suppresses gastric cancer cell proliferation via G1 arrest. • MiR-215 targets RB1 through its 3′-UTR in gastric cancer cells. • RB1 is involved in the role of miR-215...

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Veröffentlicht in:	Cancer letters 2014-01, Vol.342 (1), p.27-35
Hauptverfasser:	Deng, Yujie, Huang, Zhenxia, Xu, Yanjun, Jin, Juan, Zhuo, Wei, Zhang, Cheng, Zhang, Xuting, Shen, Minhong, Yan, Xiaoyi, Wang, Liangjing, Wang, Xiaojia, Kang, Yibin, Si, Jianmin, Zhou, Tianhua
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Aged Apoptosis Area Under Curve Base Sequence Binding Sites Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Bone cancer Cell Cycle Cell growth Cell Line, Tumor Cell Proliferation Dihydrofolate reductase Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Male Metastasis MicroRNAs - genetics MicroRNAs - metabolism MiR-215 Proliferation Proteins Retinoblastoma Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism RNA Interference ROC Curve Rodents Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Transcriptome Tumorigenesis Up-Regulation
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Zusammenfassung:	Highlights • MiR-215 is frequently up-regulated in gastric cancer and may serve as a biomarker for diagnosis. • Inhibition of miR-215 suppresses gastric cancer cell proliferation via G1 arrest. • MiR-215 targets RB1 through its 3′-UTR in gastric cancer cells. • RB1 is involved in the role of miR-215 in modulating gastric cancer cell proliferation.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.08.033