Deep inspiration volume and the impaired reversal of bronchoconstriction in asthma

Highlights • We measured deep inspiration maximal dilatation and residual dilatation. • Different deep breath volumes were compared in asthmatics and non-asthmatics. • Deep breath volume was positively associated with maximal dilatation in both groups. • In non-asthmatics, the degree of maximal dila...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2013-12, Vol.189 (3), p.506-512
Hauptverfasser:	Hulme, Kathryn M, Salome, Cheryl M, Brown, Nathan J, Berend, Norbert, Agus, Helen M, Horlyck, Karla R, King, Greg G, Chapman, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Airway hyperresponsiveness Airway physiology Analysis of Variance Asthma Asthma - drug therapy Asthma - physiopathology Bronchial Provocation Tests Bronchoconstriction - drug effects Bronchoconstriction - physiology Deep inspiration Female Forced Expiratory Volume - drug effects Humans Inspiratory Capacity - drug effects Male Medical Education Methacholine Chloride - pharmacology Methacholine Chloride - therapeutic use Muscarinic Agonists - pharmacology Muscarinic Agonists - therapeutic use Pulmonary/Respiratory Young Adult
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Zusammenfassung:	Highlights • We measured deep inspiration maximal dilatation and residual dilatation. • Different deep breath volumes were compared in asthmatics and non-asthmatics. • Deep breath volume was positively associated with maximal dilatation in both groups. • In non-asthmatics, the degree of maximal dilatation predicted residual dilatation. • In asthmatics, maximal dilatation was not related to residual dilatation.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2013.08.015