Altered plasma insulin and glucose after obesity-producing bipiperidyl brain lesions

A single systemic injection of bipiperidyl mustard (BPM) in the adult rat produces brain lesions and associated obesity without hyperphagia. To characterize some endocrine-metabolic aspects of the BPM preparation the authors measured plasma insulin and glucose dynamics as well as glucoprivic feeding. The results suggest that BPM lesions (which appears to overlap distributions of central insulin binding site) both affect a central mechanism controlling the pancreatic beta -cells and possibility influence gastric emptying and/or intestinal glucose absorption.