Impaired motor cortex plasticity in patients with Noonan syndrome
Highlights • This is the first study that indicates reduced synaptic plasticity in patients with RAS-pathway disorder. • Attention plays a crucial role in induction of synaptic plasticity in both, Noonan syndrome patients and healthy volunteers. • Learning and attention deficits in Noonan syndrome p...
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| Veröffentlicht in: | Clinical neurophysiology 2013-12, Vol.124 (12), p.2439-2444 |
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| container_issue | 12 |
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| container_title | Clinical neurophysiology |
| container_volume | 124 |
| creator | Mainberger, Florian Zenker, Martin Jung, Nikolai H Delvendahl, Igor Brandt, Antonia Freudenberg, Leonie Heinen, Florian Mall, Volker |
| description | Highlights • This is the first study that indicates reduced synaptic plasticity in patients with RAS-pathway disorder. • Attention plays a crucial role in induction of synaptic plasticity in both, Noonan syndrome patients and healthy volunteers. • Learning and attention deficits in Noonan syndrome patients could be caused by impairments in LTP-like plasticity. |
| doi_str_mv | 10.1016/j.clinph.2013.04.343 |
| format | Article |
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| ispartof | Clinical neurophysiology, 2013-12, Vol.124 (12), p.2439-2444 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Attention Developmental disorder Electric Stimulation - methods Electromyography - methods Evoked Potentials, Motor Female Humans Learning Disorders - physiopathology Long-Term Potentiation Male Motor Cortex - physiopathology Neurology Neuronal Plasticity Noonan Syndrome - physiopathology Paired associative stimulation (PAS) RAS-pathway Synapses - physiology Synaptic plasticity Transcranial Magnetic Stimulation Transcranial magnetic stimulation (TMS) |
| title | Impaired motor cortex plasticity in patients with Noonan syndrome |
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