Impaired motor cortex plasticity in patients with Noonan syndrome

Impaired motor cortex plasticity in patients with Noonan syndrome

Highlights • This is the first study that indicates reduced synaptic plasticity in patients with RAS-pathway disorder. • Attention plays a crucial role in induction of synaptic plasticity in both, Noonan syndrome patients and healthy volunteers. • Learning and attention deficits in Noonan syndrome p...

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Veröffentlicht in:Clinical neurophysiology 2013-12, Vol.124 (12), p.2439-2444
Hauptverfasser: Mainberger, Florian, Zenker, Martin, Jung, Nikolai H, Delvendahl, Igor, Brandt, Antonia, Freudenberg, Leonie, Heinen, Florian, Mall, Volker
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Attention
Developmental disorder
Electric Stimulation - methods
Electromyography - methods
Evoked Potentials, Motor
Female
Humans
Learning Disorders - physiopathology
Long-Term Potentiation
Male
Motor Cortex - physiopathology
Neurology
Neuronal Plasticity
Noonan Syndrome - physiopathology
Paired associative stimulation (PAS)
RAS-pathway
Synapses - physiology
Synaptic plasticity
Transcranial Magnetic Stimulation
Transcranial magnetic stimulation (TMS)
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Zusammenfassung:Highlights • This is the first study that indicates reduced synaptic plasticity in patients with RAS-pathway disorder. • Attention plays a crucial role in induction of synaptic plasticity in both, Noonan syndrome patients and healthy volunteers. • Learning and attention deficits in Noonan syndrome patients could be caused by impairments in LTP-like plasticity.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2013.04.343