Challenges in Interpreting the Evidence for Genetic Predictors of Ototoxicity

Challenges in Interpreting the Evidence for Genetic Predictors of Ototoxicity

There has been recent controversy regarding predictors of cisplatin‐induced ototoxicity in children, as highlighted in a previous issue of this journal. We have reviewed the two articles that purport to show an association between TPMT and COMT variants and ototoxicity, as well as the related patent...

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Veröffentlicht in:Clinical pharmacology and therapeutics 2013-12, Vol.94 (6), p.631-635
Hauptverfasser: Ratain, M J, Cox, N J, Henderson, T O
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - adverse effects
Antineoplastic Agents - toxicity
Catechol O-Methyltransferase - genetics
Cisplatin - adverse effects
Cisplatin - toxicity
Female
Genetic Variation
Hearing Loss - chemically induced
Hearing Loss - genetics
Humans
Male
Methyltransferases - genetics
Multidrug Resistance-Associated Proteins - genetics
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Zusammenfassung:There has been recent controversy regarding predictors of cisplatin‐induced ototoxicity in children, as highlighted in a previous issue of this journal. We have reviewed the two articles that purport to show an association between TPMT and COMT variants and ototoxicity, as well as the related patent applications dating back to 2006. We summarize statistical issues not fully addressed by the authors that appear to have confounded the results of their studies. Clinical Pharmacology & Therapeutics (2013); 94 6, 631–635. doi:10.1038/clpt.2013.178
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2013.178