New Biologically Active Hydrogen Sulfide Donors

Generous donors: The dithioperoxyanhydrides (CH3COS)2, (PhCOS)2, CH3COSSCO2Me and PhCOSSCO2Me act as thiol‐activated hydrogen sulfide donors in aqueous buffer solution. The most efficient donor (CH3COS)2 can induce a biological response in cells, and advantageously replace hydrogen sulfide in ex viv...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2013-11, Vol.14 (17), p.2268-2271
Hauptverfasser:	Roger, Thomas, Raynaud, Francoise, Bouillaud, Frédéric, Ransy, Céline, Simonet, Serge, Crespo, Christine, Bourguignon, Marie-Pierre, Villeneuve, Nicole, Vilaine, Jean-Paul, Artaud, Isabelle, Galardon, Erwan
Format:	Artikel
Sprache:	eng
Schlagworte:	biological activity Disulfides - chemical synthesis Disulfides - chemistry Disulfides - metabolism dithioperoxyanhydrides hydrogen sulfide Hydrogen Sulfide - chemistry Hydrogen Sulfide - metabolism Molecular Structure oxidoreductases SQR vasorelaxation
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Beschreibung
Zusammenfassung:	Generous donors: The dithioperoxyanhydrides (CH3COS)2, (PhCOS)2, CH3COSSCO2Me and PhCOSSCO2Me act as thiol‐activated hydrogen sulfide donors in aqueous buffer solution. The most efficient donor (CH3COS)2 can induce a biological response in cells, and advantageously replace hydrogen sulfide in ex vivo vascular studies.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201300552