Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus

•We report the structures of 4 sialoside receptor analogues complexed with H5 HA.•The analogues included fucosylated and/or sulphated GlcNAc at position 3.•Estimates of affinity of HA for the analogues were made by biolayer interferometry.

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Bibliographische Detailangaben
Veröffentlicht in:	Virus research 2013-12, Vol.178 (1), p.12-14
Hauptverfasser:	Xiong, X., Tuzikov, A., Coombs, P.J., Martin, S.R., Walker, P.A., Gamblin, S.J., Bovin, N., Skehel, J.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - metabolism Humans Influenza A Virus, H5N1 Subtype - chemistry Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - metabolism Influenza, Human - genetics Influenza, Human - metabolism Influenza, Human - virology Models, Molecular Molecular Structure Protein Binding Receptors, Virus - chemistry Receptors, Virus - genetics Receptors, Virus - metabolism
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Beschreibung
Zusammenfassung:	•We report the structures of 4 sialoside receptor analogues complexed with H5 HA.•The analogues included fucosylated and/or sulphated GlcNAc at position 3.•Estimates of affinity of HA for the analogues were made by biolayer interferometry.
ISSN:	0168-1702 1872-7492
DOI:	10.1016/j.virusres.2013.08.007