Aogacillins A and B Produced by Simplicillium sp. FKI-5985: New Circumventors of Arbekacin Resistance in MRSA

Aogacillins A and B, capable of overcoming arbekacin resistance in methicillin-resistant Staphylococcus aureus (MRSA), were isolated from a culture broth of Simplicillium sp. FKI-5985. Their structures were elucidated by NMR spectroscopic studies and ECD analyses. The aogacillins possessed a novel c...

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Veröffentlicht in:	Organic letters 2013-09, Vol.15 (18), p.4678-4681
Hauptverfasser:	Takata, Keiko, Iwatsuki, Masato, Yamamoto, Tsuyoshi, Shirahata, Tatsuya, Nonaka, Kenichi, Masuma, Rokuro, Hayakawa, Yoichi, Hanaki, Hideaki, Kobayashi, Yoshinori, Petersson, George A, O̅mura, Satoshi, Shiomi, Kazuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Cyclohexanes - chemistry Cyclohexanes - isolation & purification Cyclohexanes - pharmacology Hypocreales - chemistry Methicillin Resistance - drug effects Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Molecular Structure Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - pharmacology
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Zusammenfassung:	Aogacillins A and B, capable of overcoming arbekacin resistance in methicillin-resistant Staphylococcus aureus (MRSA), were isolated from a culture broth of Simplicillium sp. FKI-5985. Their structures were elucidated by NMR spectroscopic studies and ECD analyses. The aogacillins possessed a novel carbon skeleton, including a β-keto-γ-methyliden-δ-lactone ring connected to a 2-ethyl-6-methylcyclohexane ring by spiro conjugation.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol401975z