Fluorescent Sensor Based on BINOL for Recognition of Cysteine, Homocysteine, and Glutathione

A new and simple fluorescent sensor based on unmodified BINOL was developed. The fluorescence of BINOL could be turned off with high selectivity toward Cu(II) among 27 metal ions. Meanwhile, it was found that BINOL was oxidized to dibenzo[a,kl]xanthen-1-ol (A) by Cu(NO3)2. A new peak appeared at ∼48...

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Veröffentlicht in:Journal of organic chemistry 2013-11, Vol.78 (22), p.11602-11605
Hauptverfasser: Peng, Ruixue, Lin, Lili, Wu, Xiaoxia, Liu, Xiaohua, Feng, Xiaoming
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container_issue 22
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container_title Journal of organic chemistry
container_volume 78
creator Peng, Ruixue
Lin, Lili
Wu, Xiaoxia
Liu, Xiaohua
Feng, Xiaoming
description A new and simple fluorescent sensor based on unmodified BINOL was developed. The fluorescence of BINOL could be turned off with high selectivity toward Cu(II) among 27 metal ions. Meanwhile, it was found that BINOL was oxidized to dibenzo[a,kl]xanthen-1-ol (A) by Cu(NO3)2. A new peak appeared at ∼482 nm upon addition of thiol-containing cysteine (Cys), homocysteine (Hcy), and glutathione (GSH). Thus, a cascade recognition of Cu(II) and Cys, Hcy, and GSH are well presented.
doi_str_mv 10.1021/jo401932n
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subjects Copper - analysis
Cysteine - analysis
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Glutathione - analysis
Homocysteine - analysis
Molecular Structure
Naphthols - chemical synthesis
Naphthols - chemistry
title Fluorescent Sensor Based on BINOL for Recognition of Cysteine, Homocysteine, and Glutathione
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