Fluorescent Sensor Based on BINOL for Recognition of Cysteine, Homocysteine, and Glutathione

Fluorescent Sensor Based on BINOL for Recognition of Cysteine, Homocysteine, and Glutathione

A new and simple fluorescent sensor based on unmodified BINOL was developed. The fluorescence of BINOL could be turned off with high selectivity toward Cu(II) among 27 metal ions. Meanwhile, it was found that BINOL was oxidized to dibenzo[a,kl]xanthen-1-ol (A) by Cu(NO3)2. A new peak appeared at ∼48...

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Veröffentlicht in:Journal of organic chemistry 2013-11, Vol.78 (22), p.11602-11605
Hauptverfasser: Peng, Ruixue, Lin, Lili, Wu, Xiaoxia, Liu, Xiaohua, Feng, Xiaoming
Format: Artikel
Sprache:eng
Schlagworte:
Copper - analysis
Cysteine - analysis
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Glutathione - analysis
Homocysteine - analysis
Molecular Structure
Naphthols - chemical synthesis
Naphthols - chemistry
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Beschreibung
Zusammenfassung:A new and simple fluorescent sensor based on unmodified BINOL was developed. The fluorescence of BINOL could be turned off with high selectivity toward Cu(II) among 27 metal ions. Meanwhile, it was found that BINOL was oxidized to dibenzo[a,kl]xanthen-1-ol (A) by Cu(NO3)2. A new peak appeared at ∼482 nm upon addition of thiol-containing cysteine (Cys), homocysteine (Hcy), and glutathione (GSH). Thus, a cascade recognition of Cu(II) and Cys, Hcy, and GSH are well presented.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo401932n